Other patients chimed in, sharing successful results from the combo. I made a mental note, I would have to try this in a bind. The time is now…. That afternoon, I high tailed it to Walgreens, bound and determined to try this mysterious combo, practically unknown to the MPN world. I was already taking 1 10 mg Zyrtec in the morning for allergies and added 2 mg Zantac to my routine, one in the morning and one at night.
It provided itching relief quickly…. Miraculous relief that I hope will be helpful to many fellow MPN patients. It should be noted that generic versions Cetirizine Hydrochloride Zyrtec and Ranitidine Zantac can be purchased from Costco or Walmart for a considerable discount from the branded versions.
Note: Before taking any medications, even OTC, be sure to check with your doctor or pharmacist. Here are more strategies to Beat Itching in Polycythemia Vera.
Mast cells have long been known to contribute to the discomforts of mankind by releasing histamine and producing the miseries of allergies. However, patients with mast cell disease may also present with a multitude of disparate symptoms such as arthritis, GERD, constipation, malabsorption, cramping, severe abdominal bloating, short term memory problems, headache, nausea, bone pain, heart palpitations, changes in cognitive function and mood and more. Sound familiar? Mastocytosis, one of the myriad of mast cell diseases are classified as an MPN , so no surprise there!
Mast cell activation syndrome is a fancy way of saying the immune system is freaking out and dumping inflammation into the body, sometimes chronically. While mast cells present throughout the body, all body tissues that come in direct contact with the outside world have mast cells and they are concentrated in the skin, gut, nasal passages, lung, urinary tract and other mucus membranes. With MPNs, we suffer with excess histamine due to basophil breakdown a type of white blood cell.
Histamine is one of the inflammatory players released by mast cells, along with heparin and serotonin. Is Zantac An Antihistamine? Answered By: Dr. Adam DeRue Pharm. Mar 24, Was this article helpful? We'll never share your email with anyone else. Submit Close. Derue44 gmail. Related Questions. One is that chronic hives are caused by changes in white blood cells called basophils.
Another is that some people begin to make antibodies proteins that normally fight infections that cause cells mast cells to release natural chemicals. These mast cells are in the skin, and the chemicals cause swelling in the skin around the cells, creating hives. However, a small number of unfortunate people have chronic hives for years on end. Many people with hives notice that the symptoms seem to be related to diet in some way, but testing for food allergy usually shows that a person with hives is not allergic to any food.
This is because while some foods contain natural chemicals that aggravate hives, there are so many foods that do this that avoiding enough of them to make a real difference in the symptoms would be difficult and impractical. People with hives almost always require antihistamines to control the symptoms. Antihistamines are considered the safest and most effective initial treatment. Certain antihistamines, such as cetirizine Zyrtec , fexofenadine Allegra , and loratadine Claritin , cause less drowsiness and dry mouth than others, such as diphenhydramine Benadryl and chlorpheniramine.
Doctors often need to combine different types of antihistamines or double the dose of one medicine. To figure out the right medication or combination of medications for your daughter, you'll need to discuss with her doctor her age and how well she responds to the various medications. If hives are still not controlled on full doses of two or more antihistamines, many doctors will add a medicine called montelukast Singulair for a month or so, and some patients then improve.
Every patient is different, though, and it can take weeks to find a set of medicines that work. The process can be frustrating, so be patient. I have had chronic hives for the past six months. The only thing that controls them temporarily is prednisone. As soon as I am off of it, they come back with a vengeance within 24 hours or less. Is there anything else that might help? I already take Zyrtec and Zantac.
I am desperate and would appreciate any suggestions. Hives are raised, intensely itchy spots or patches that appear in crops, last for a few hours, and then resolve without leaving any residual marks on the skin. They can range in size from as big as a pencil eraser to the size of a dinner plate. Hives can appear anywhere on the body, although the legs, arms, abdomen, armpits, and neck are the areas where they most commonly surface.
Most people will develop hives at least once in their lives, and the trigger is often not obvious. For a benign condition, hives certainly cause a lot of suffering for those that have them.
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